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. 2006 Mar-Apr;58(2):246-9.

Search for drugs of the combined anti-inflammatory and anti-bacterial properties: 1-methyl-N'-(hydroxymethyl)nicotinamide

Maciej Adamiec  1 , Jan Adamus, Ireneusz Ciebiada, Andrzej Denys, Jerzy Gebicki
Affiliations
  • PMID: 16702628
Free article

Search for drugs of the combined anti-inflammatory and anti-bacterial properties: 1-methyl-N'-(hydroxymethyl)nicotinamide

Maciej Adamiec et al. Pharmacol Rep. 2006 Mar-Apr.
Free article

Abstract

It has already been reported that 1-methylnicotinamide (MNA+), a primary metabolite of nicotinamide (vitamin B3), possesses remarkable anti-inflammatory properties [3]. This communication shows that 1-methyl-N'-(hydroxymethyl)nicotinamide (MNAF+ can be regarded as MNA+ precursor able to release simultaneously formaldehyde. Therefore, MNAF+ can be viewed as a candidate for drug with the combined anti-inflammatory and anti-bacterial properties.

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