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Comment
. 2006 Jun 1;396(2):e9-11.
doi: 10.1042/bj20060545.

Cleavage, a real turn-off? HIV-mediated proteolysis of PABP1

Brian Collier  1 , Nicola K Gray
Affiliations
Comment

Cleavage, a real turn-off? HIV-mediated proteolysis of PABP1

Brian Collier et al. Biochem J. .

Abstract

In this issue of the Biochemical Journal, Alvarez and colleagues have identified PABP1 [poly(A)-binding protein 1] as a target of protease cleavage during HIV infection. The study shows that HIV-1, HIV-2 and mouse mammary tumour virus, but not other retroviruses, target PABP1 for cleavage and identifies cleavage sites within the RNA-recognition motifs and C-terminal region of the protein. This suggests that PABP1 cleavage may be important in the shut-off of host translation during HIV infection. This extends the viral families that are known to target PABP1 to include Retroviridae, suggesting that PABP1 may be a central target of viral infection.

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References

    1. Bushell M., Sarnow P. Hijacking the translation apparatus by RNA viruses. J. Cell Biol. 2002;158:395–399. - PMC - PubMed
    1. Jackson R. J. Alternative mechanisms of initiating translation of mammalian mRNAs. Biochem. Soc. Trans. 2005;33:1231–1241. - PubMed
    1. Gorgoni B., Gray N. K. The role of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective. Brief Funct. Genomics Proteomics. 2004;3:125–141. - PubMed
    1. Kuyumcu-Martinez M., Belliot G., Sosnovtsev S. V., Chang K. O., Green K. Y., Lloyd R. E. Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein. J. Virol. 2004;78:8172–8182. - PMC - PubMed
    1. Joachims M., Van Breugel P. C., Lloyd R. E. Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J. Virol. 1999;73:718–727. - PMC - PubMed

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