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. 2006 Jun;154(6):1180-3.
doi: 10.1111/j.1365-2133.2006.07180.x.

Interleukin 12 production by monocytes from patients with psoriasis and its inhibition by ciclosporin A

Y Tada  1 , A Asahina, T Takekoshi, E Kishimoto, H Mitsui, H Saeki, M Komine, K Tamaki
Affiliations

Interleukin 12 production by monocytes from patients with psoriasis and its inhibition by ciclosporin A

Y Tada et al. Br J Dermatol. 2006 Jun.

Abstract

Background: Psoriasis is a T-helper (Th)1 cytokine-mediated chronic skin disease and interleukin (IL)-12 has been shown to play a major role in the development of Th1 responses.

Objectives: To elucidate the role of IL-12 in the pathogenesis of psoriasis and to study the effect of ciclosporin A (CsA) on Th1 deviation of this disease.

Patients/methods: We investigated IL-12 production by stimulated monocytes from patients with psoriasis who were treated with or without CsA. Monocytes were stimulated with interferon-gamma plus lipopolysaccharide (LPS) or Staphylococcus aureus Cowan strain I (SAC). The amount of IL-12 p70 produced by stimulated monocytes was evaluated by enzyme-linked immunosorbent assay.

Results: Compared with those from normal controls, LPS- but not SAC-stimulated monocytes from patients with psoriasis produced significantly higher amounts of IL-12. Interestingly, LPS-stimulated monocytes from patients with psoriasis treated with CsA produced significantly decreased amounts of IL-12 compared with those patients not treated with CsA.

Conclusions: Our results suggest that IL-12 production by monocytes may have a critical role in the pathogenesis of psoriasis, and that the therapeutic effect of CsA on psoriasis may be achieved by correcting the deviation of the Th1/Th2 balance.

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