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. 2006 Mar;12(3):492-4.
doi: 10.3201/eid1203.050839.

Canine coronavirus highly pathogenic for dogs

Canio Buonavoglia  1 , Nicola Decaro, Vito Martella, Gabriella Elia, Marco Campolo, Costantina Desario, Massimo Castagnaro, Maria Tempesta
Affiliations

Canine coronavirus highly pathogenic for dogs

Canio Buonavoglia et al. Emerg Infect Dis. 2006 Mar.

Abstract

Canine coronavirus (CCoV) is usually responsible for mild, self-limiting infections restricted to the enteric tract. We report an outbreak of fatal disease in puppies caused by a pathogenic variant of CCoV that was isolated from organs with severe lesions.

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Figures

Figure 1
Figure 1
Immunohistochemical detection of canine coronavirus antigen (arrows) in canine lung tissue by a specific monoclonal antibody (magnification ×400).
Figure 2
Figure 2
Neighbor-joining tree of the spike protein of canine coronavirus (CCoV) and feline coronavirus (FCoV). The following reference strains were used for phylogenetic analysis: CCoV type I strains Elmo/02 (GenBank accession no. AY307020) and 23/03 (AY307021); CCoV type II strains Insavc-1 (D13096) and K378 (X77047); FCoV type I strains KU-2 (D32044), Black (AB088223) and UCD-1 (AB088222); FCoV type II strains 79-1146 (X06170) and 79-1683 (X80799); and bovine coronavirus (BCoV) strain ENT (NC_003045). The tree is rooted on BCoV-ENT and drawn to scale. A statistical support was provided by bootstrapping >100 replicates. The scale bar represents 20 substitutions per 100 sequence positions.feline coronavirus (FCoV). The following reference strains were used for phylogenetic analysis: CCoV type I strains Elmo/02 (GenBank accession no. AY307020) and 23/03 (AY307021); CCoV type II strains Insavc-1 (D13096) and K378 (X77047); FCoV type I strains KU-2 (D32044), Black (AB088223) and UCD-1 (AB088222); FCoV type II strains 79-1146 (X06170) and 79-1683 (X80799); and bovine coronavirus (BCoV) strain ENT (NC_003045). The tree is rooted on BCoV-ENT and drawn to scale. A statistical support was provided by bootstrapping >100 replicates. The scale bar represents 20 substitutions per 100 sequence positions.
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References

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