Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Apr;12(4):675-7.
doi: 10.3201/eid1204.051418.

Shrews as reservoir hosts of borna disease virus

Monika Hilbe  1 , Romana Herrsche, Jolanta Kolodziejek, Norbert Nowotny, Kati Zlinszky, Felix Ehrensperger
Affiliations

Shrews as reservoir hosts of borna disease virus

Monika Hilbe et al. Emerg Infect Dis. 2006 Apr.

Abstract

Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other animal species in central Europe. Here we report the first unequivocal detection of a BDV reservoir species, the bicolored white-toothed shrew, Crocidura leucodon, in an area in Switzerland with endemic Borna disease.

PubMed Disclaimer

Figures

Figure
Figure
A) Distribution of Borna disease virus (BDV) p24 antigen in the hippocampus of shrew 144. Note the so-called Joest-Degen intranuclear inclusion bodies in multiple neurons in the gyrus dentatus; in some neurons, a homogenous intracytoplasmic staining can be seen (immunohistochemistry, ChemMate method [DAKO, Cygomation, Zug, Switzerland], ×40 [bar, 100 μm]). Inset: Joest-Degen intranuclear inclusion bodies are visible in multiple neurons in the gyrus dentatus (ChemMate method, ×100). B) Focal distribution of BDV p38/40 antigen in the heart of shrew 144: granular intracytoplasmic and homogenous intranuclear labeling (ChemMate method, ×40 [bar, 100 μm]).
See this image and copyright information in PMC

References

    1. Nowotny N, Kolodziejek J, Jehle CO, Suchy A, Staeheli P, Schwemmle M. Isolation and characterization of a new subtype of Borna disease virus. J Virol. 2000;74:5655–8. 10.1128/JVI.74.12.5655-5658.2000 - DOI - PMC - PubMed
    1. Pleschka S, Staeheli P, Kolodziejek J, Richt JA, Nowotny N, Schwemmle M. Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus. J Gen Virol. 2001;82:2681–90. - PubMed
    1. Kolodziejek J, Dürrwald R, Herzog S, Ehrensperger F, Lussy H, Nowotny N. Genetic clustering of Borna disease virus natural animal isolates, laboratory and vaccine strains strongly reflects their regional geographical origin. J Gen Virol. 2005;86:385–98. 10.1099/vir.0.80587-0 - DOI - PubMed
    1. Jordan I, Lipkin WI. Borna disease virus. Rev Med Virol. 2001;11:37–8. 10.1002/rmv.300 - DOI - PMC - PubMed
    1. Schindler AR. Real Time RT-PCR for tracing and quantification of Borna disease virus RNA in diseased hosts compared to experimentally inoculated ticks. Doctoral thesis, University of Zürich. 2004. Available from http://www.dissertationen.unizh.ch/namenalphabet.html

LinkOut - more resources