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Case Reports
. 2006 May;12(5):775-9.
doi: 10.3201/eid1205.051316.

Coronavirus HKU1 infection in the United States

Frank Esper  1 , Carla Weibel, David Ferguson, Marie L Landry, Jeffrey S Kahn
Affiliations
Case Reports

Coronavirus HKU1 infection in the United States

Frank Esper et al. Emerg Infect Dis. 2006 May.

Abstract

In 2005, a new human coronavirus, HCoV-HKU1, was identified in Hong Kong. We screened respiratory specimens collected from December 16, 2001, to December 15, 2002, from children <5 years of age who tested negative for respiratory syncytial virus, parainfluenza viruses, influenza virus, and adenovirus for HCoV-HKU1 by reverse transcription-polymerase chain reaction. Overall, 1,048 respiratory specimens from 851 children were tested, and 9 HCoV-HKU1-positive children (1%) were identified, 2 of whom had 2 positive specimens. Children who had HCoV-HKU1 infection had evidence of either upper or lower respiratory tract infection or both. Two patients had disease beyond the respiratory tract. HCoV-HKU1 was identified from December 2001 to February 2002. Sequence analyses suggest that a single strain was circulating. HCoV-HKU1 is therefore likely circulating in the United States and is associated with upper and lower respiratory tract disease.

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Figures

Figure
Figure
Weekly distribution of human coronavirus (HCoV)-HKU1 infection in children <5 years of age, December 16, 2001, to December 15, 2002, New Haven, Connecticut. The weekly distributions of HCoV-HKU1 isolates are shown as gray bars (left axis). The total number of samples collected by week are indicated by black bars (right axis).
See this image and copyright information in PMC

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