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Review
. 2006 Jun;16(3):251-7.
doi: 10.1016/j.conb.2006.05.002. Epub 2006 May 15.

Homer proteins: implications for neuropsychiatric disorders

Karen K Szumlinski  1 , Peter W Kalivas, Paul F Worley
Affiliations
Review

Homer proteins: implications for neuropsychiatric disorders

Karen K Szumlinski et al. Curr Opin Neurobiol. 2006 Jun.

Abstract

Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.

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