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. 2006 Summer;9(2):211-4.
doi: 10.1089/rej.2006.9.211.

Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content

P Cassano  1 , A G Sciancalepore, A M S Lezza, C Leeuwenburgh, P Cantatore, M N Gadaleta
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Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content

P Cassano et al. Rejuvenation Res. 2006 Summer.

Abstract

The effect of age and caloric-restriction (CR) diet on mitochondrial DNA (mtDNA) content in different rat tissues was investigated. A decrease of the mtDNA content occurs with aging in liver and soleus muscle, whereas there is no age-related significant change of mtDNA content in brain. CR fully reverses the age-dependent loss of mtDNA in liver and soleus, whereas it results in a significant increase of mtDNA amount above the value of aged ad libitum fed rats in brain. These results further support the tissue-specific effect of CR, likely because of the different dependence of tissues on external nutrient uptake.

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