doi: 10.1128/mcb.11.1.554-557.1991.
The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts
Affiliations
- PMID: 1670897
- PMCID: PMC359666
- DOI: 10.1128/mcb.11.1.554-557.1991
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The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts
Mol Cell Biol.
1991 Jan.
Abstract
The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.
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