Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Jan;11(1):554-7.
doi: 10.1128/mcb.11.1.554-557.1991.

The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts

D Aberdam  1 , V Negreanu, L Sachs, C Blatt
Affiliations

The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts

D Aberdam et al. Mol Cell Biol. 1991 Jan.

Abstract

The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.

PubMed Disclaimer

References

    1. Science. 1983 Nov 18;222(4625):771-8 - PubMed
    1. Biochem Biophys Res Commun. 1988 Nov 15;156(3):1265-70 - PubMed
    1. Nature. 1980 Oct 30;287(5785):795-801 - PubMed
    1. Nature. 1978 Dec 7;276(5688):565-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jan;74(1):253-7 - PubMed

Publication types

LinkOut - more resources