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Case Reports
. 2006 May;91(5 Suppl):ECR09.

Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia

Giuseppe Germano  1 , Martina Pigazzi, Laura del Giudice, Marta Campo Dell'Orto, Monica Spinelli, Andrea Zangrando, Paolo Paolucci, Saverio Ladogana, Giuseppe Basso
Affiliations
  • PMID: 16709517
Free article
Case Reports

Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia

Giuseppe Germano et al. Haematologica. 2006 May.
Free article

Abstract

An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.

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