Neuromyelitis optica and anti-aquaporin-4 antibodies: widening the clinical phenotype

Editorial

G Giovannoni. J Neurol Neurosurg Psychiatry. 2006 Sep.

. 2006 Sep;77(9):1001-2.

doi: 10.1136/jnnp.2006.090944. Epub 2006 May 18.

Abstract

Presence of anti‐aquaporin‐4 antibodies in patients with neuromyelitis optica has wide implications

Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG.
Nakashima I, Fujihara K, Miyazawa I, Misu T, Narikawa K, Nakamura M, Watanabe S, Takahashi T, Nishiyama S, Shiga Y, Sato S, Weinshenker BG, Itoyama Y. Nakashima I, et al. J Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1073-5. doi: 10.1136/jnnp.2005.080390. Epub 2006 Feb 27. J Neurol Neurosurg Psychiatry. 2006. PMID: 16505005 Free PMC article.

1. Weinshenker B G. Neuromyelitis optica: what it is and what it might be. Lancet 2003361889–890. - PubMed
1. Weinshenker B. Western vs optic‐spinal MS: two diseases, one treatment? Neurology 200564594–595. - PubMed
1. Lucchinetti C F, Mandler R N, McGavern D.et al A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain 20021251450–1461. - PMC - PubMed
1. Lennon V A, Wingerchuk D M, Kryzer T J.et al A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 20043642106–2112. - PubMed
1. Lennon V A, Kryzer T J, Pittock S J.et al IgG marker of optic‐spinal multiple sclerosis binds to the aquaporin‐4 water channel. J Exp Med 2005202473–477. - PMC - PubMed