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. 1975 Aug 1;142(2):530-5.
doi: 10.1084/jem.142.2.530.

Fibroblast surface antigen produced but not retained by virus-transformed human cells

A Vaheri, E Ruoslahti

Fibroblast surface antigen produced but not retained by virus-transformed human cells

A Vaheri et al. J Exp Med. .

Abstract

Normal human fibroblasts contain a cell type-specific glycoprotein antigen (SF) that is known to be slowly shed into the medium and to be present also in human serum. Immunofluorescence with anti-SF antibodies showed that SF antigen has a highly nonrandom fibrillar distribution in surface of normal fibroblasts. Simian virus 40-transformed fibroblasts also produced the SF antigen, as shown by radioimmunoassay or immunodiffusion tests, but it was not retained by the surface of these cells. This creates a major difference between the surfaces of normal and malignant cells.

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References

    1. Biochim Biophys Acta. 1975 Jan 30;379(1):295-303 - PubMed
    1. J Exp Med. 1975 Feb 1;141(2):497-501 - PubMed
    1. Biochem J. 1963 Oct;89:114-23 - PubMed
    1. J Cell Physiol. 1965 Feb;65:69-83 - PubMed
    1. J Biol Chem. 1970 Nov 10;245(21):5728-36 - PubMed