Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 May-Jun;16(3):187-202.
doi: 10.1002/rmv.499.

Vaccinia virus proteolysis--a review

Affiliations
Review

Vaccinia virus proteolysis--a review

Chelsea M Byrd et al. Rev Med Virol. 2006 May-Jun.

Abstract

It is well known that viruses, as obligate intracellular parasites, must use their hosts' metabolic machinery in order to replicate their genomes and form infectious progeny virions. What is less well known are the details of how viruses make sure that once all the necessary proteins are made, that they assume the correct configuration at the proper time in order to catalyse the efficient assembly of infectious virions. One of the methods employed by viruses to regulate this process is the proteolytic cleavage of viral proteins. Over the past several decades, studies in numerous laboratories have demonstrated that morphogenic proteolysis plays a major and essential role during the assembly and maturation of infectious poxvirus virions. In this review we describe the history of vaccinia virus proteolysis as a prototypic viral system.

PubMed Disclaimer

References

    1. Linderstrom‐Lang KU, Ottesen M. Formation of plakalbumin from ovalbumin. Comp Rend Trav Lab Carlsberg 1949; 26: 403–412.
    1. Polgar L. Mechanisms of protease action. CRC Press: Boca Raton, Florida, 1989.
    1. Dougherty WG, Semler BL. Expression of virus‐encoded proteinases: functional and structural similarities with cellular enzymes. Microbiol Rev 1993; 57: 781–822. - PMC - PubMed
    1. Polgar L. Structure and function of serine proteinases In New Comprehensive Biochemistry (Vol. 16) Brocklehurst ANaK. (ed.). Elsevier: Amsterdam, 1987.
    1. Loeb DD, Hutchison CA, Edgell MH, Farmerie WG, Swanstrom R. Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases. J Virol 1989; 63: 111–121. - PMC - PubMed

Publication types