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Comment
. 2006 May 19;125(4):647-9.
doi: 10.1016/j.cell.2006.05.008.

Using isoform-specific inhibitors to target lipid kinases

Julian A Simon  1
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Free article
Comment

Using isoform-specific inhibitors to target lipid kinases

Julian A Simon. Cell. .
Free article

Abstract

In this issue of Cell, Knight et al. (2006) present a detailed pharmacological analysis of the PI3 kinase (PI3-K) family using small molecule inhibitors. They conclude that p110alpha, a PI3-K isoform, has a critical role in insulin signaling. In a related Cancer Cell paper, Fan et al. (2006) show that blocking activation of both p110alpha and the kinase mTOR with a small molecule inhibitor limits the growth of gliomas.

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