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Review
. 2006 May 19;22(4):432-3.
doi: 10.1016/j.molcel.2006.05.006.

A confederacy of kinases: Cdk2 and Cdk4 conspire to control embryonic cell proliferation

Philip W Hinds  1
Affiliations
Free article
Review

A confederacy of kinases: Cdk2 and Cdk4 conspire to control embryonic cell proliferation

Philip W Hinds. Mol Cell. .
Free article

Abstract

The mouse embryo is surprisingly resistant to loss of individual cyclins or cyclin-dependent kinases. In a recent issue of Developmental Cell, Berthet et al. (2006) describe collaboration of Cdk2 and Cdk4 in embryogenesis that is revealed only upon their simultaneous loss, resulting in inappropriate activation of the retinoblastoma protein and embryonic lethality.

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