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Review
. 2006 May 19;22(4):436-7.
doi: 10.1016/j.molcel.2006.05.005.

Autophagy by ARF: a short story

Charles J Sherr  1
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Free article
Review

Autophagy by ARF: a short story

Charles J Sherr. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Reef et al. (2006) describe a shortened unstable form of the ARF tumor suppressor protein that localizes within mitochondria, where it reduces membrane potential and triggers autophagy. Could this account for the Mdm2- and p53-independent tumor suppressive effects of ARF?

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