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. 2006 Jul 1;540(1-3):82-6.
doi: 10.1016/j.ejphar.2006.04.021. Epub 2006 Apr 28.

Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain

Kazuhide Takeyama  1 , Masanobu Yoshikawa, Tetsuo Oka, Mitsuru Kawaguchi, Toshiyasu Suzuki, Atsushi Hashimoto
Affiliations

Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain

Kazuhide Takeyama et al. Eur J Pharmacol. .

Abstract

We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors.

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