Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul;59(1):15-26.
doi: 10.1016/j.critrevonc.2005.12.003. Epub 2006 May 22.

Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota  1 , Gregg L Semenza
Affiliations
Review

Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota et al. Crit Rev Oncol Hematol. 2006 Jul.

Abstract

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources