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. 1991 Mar;11(3):1745-50.
doi: 10.1128/mcb.11.3.1745-1750.1991.

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene

D H Yu  1 , K Scorsone, M C Hung
Affiliations

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene

D H Yu et al. Mol Cell Biol. 1991 Mar.

Abstract

The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.

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