Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 May 30;103(22):8305-6.
doi: 10.1073/pnas.0602526103. Epub 2006 May 22.

Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections

Affiliations
Comment

Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections

Dao Nguyen et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: No conflicts declared.

Figures

Fig. 1.
Fig. 1.
The factors needed for acute infections are generally well understood, whereas those needed for chronic infection are not. Bacterial functions needed for acute infection are selected against in chronic CF infections.
Fig. 2.
Fig. 2.
Hypothetical phylogenetic trees of bacterial evolution in chronic infections. The blue dot represents the initial infecting strain, and the black dots represent genetic variants descendent from the initial strain. Evolution could produce a dominant adapted strain or a diverse community of infecting bacteria.

Comment on

References

    1. Burns J. L., Gibson R. L., McNamara S., Yim D., Emerson J., Rosenfeld M., Hiatt P., McCoy K., Castile R., Smith A. L., Ramsey B. W. J. Infect. Dis. 2001;183:444–452. - PubMed
    1. Romling U., Fiedler B., Bosshammer J., Grothues D., Greipel J., von der Hardt H., Tummler B. J. Infect. Dis. 1994;170:1616–1621. - PubMed
    1. Smith E. E., Buckley D. G., Wu Z., Saenphimmachak C., Hoffman L. R., D’Argenio D. A., Miller S. I., Ramsey B. W., Speert D. P., Moskowitz S. M., et al. Proc. Natl. Acad. Sci. USA. 2006;103:8487–8492. - PMC - PubMed
    1. Crow J. F., Kimura M. An Introduction to Population Genetics Theory. New York: Harper & Row; 1970.
    1. Hancock R. E., Mutharia L. M., Chan L., Darveau R. P., Speert D. P., Pier G. B. Infect. Immun. 1983;42:170–177. - PMC - PubMed

MeSH terms