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Case Reports
. 2006 Apr;83(3):252-3.
doi: 10.1532/IJH97.E0515.

Bilateral osteonecrosis of the head of the femur during treatment with retinoic acid in a young patient with acute promyelocytic leukemia

Miho Sakakura  1 , Kazuhiro Nishii, Eiji Usui, Fumihiko Monma, Tetsuya Tsukada, Hiroshi Shiku
Affiliations
Case Reports

Bilateral osteonecrosis of the head of the femur during treatment with retinoic acid in a young patient with acute promyelocytic leukemia

Miho Sakakura et al. Int J Hematol. 2006 Apr.

Abstract

All-trans retinoic acid (ATRA) is the drug of choice for the treatment of acute promyelocytic leukemia (APL). In general, ATRA is well tolerated, but it does have side effects, the most severe of which is ATRA syndrome. We report the case of a young patient with APL treated with ATRA for induction and maintenance therapy who then developed avascular necrosis of both femoral heads. We also review cases of APL patients with osteonecrosis of the femoral head after ATRA therapy.

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