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. 1991 Mar;63(3):444-6.
doi: 10.1038/bjc.1991.102.

The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer

S M O'Reilly  1 , D M Barnes, R S Camplejohn, J Bartkova, W M Gregory, M A Richards
Affiliations
Free PMC article

The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer

S M O'Reilly et al. Br J Cancer. 1991 Mar.
Free PMC article

Abstract

The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer. c-erbB-2 staining was independent of age, tumour size, number of nodes involved, tumour grade and DNA ploidy, but was more common in oestrogen receptor (ER) negative tumours (P = 0.02) and progesterone receptor (PgR) negative tumours (P = 0.03). A weak correlation between c-erbB-2 staining and SPF was observed (r = 0.18). Amongst women with node negative disease, SPF was significantly related to relapse free survival (RFS, P = 0.04) while c-erbB-2 staining was not (P = 0.2). In contrast, both SPF (P = 0.002) and c-erbB-2 staining (P = 0.016) provided significant prognostic information on RFS for women with node positive disease. Multivariate analysis showed that c-erbB-2 staining and SPF gave independent information on RFS for women with node positive disease.

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References

    1. Science. 1988 Jun 24;240(4860):1795-8 - PubMed
    1. Br J Cancer. 1988 Oct;58(4):448-52 - PubMed
    1. Br J Cancer. 1990 May;61(5):671-4 - PubMed
    1. Radiat Environ Biophys. 1975 Jun 13;12(1):31-9 - PubMed
    1. J Clin Oncol. 1990 Dec;8(12):2040-6 - PubMed