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. 1991 Mar;63(3):447-50.
doi: 10.1038/bjc.1991.103.

The long term prognostic significance of c-erbB-2 in primary breast cancer

J Winstanley  1 , T Cooke, G D Murray, A Platt-Higgins, W D George, S Holt, M Myskov, A Spedding, B R Barraclough, P S Rudland
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Free PMC article

The long term prognostic significance of c-erbB-2 in primary breast cancer

J Winstanley et al. Br J Cancer. 1991 Mar.
Free PMC article

Abstract

The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

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