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Clinical Trial
. 2006 Jul 17;24(29-30):5726-33.
doi: 10.1016/j.vaccine.2006.04.037. Epub 2006 May 8.

Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: comparison with Glaxo-Evans 1077 BCG vaccine

Patricia Gorak-Stolinska  1 , Rosemary E Weir, Sian Floyd, Maeve K Lalor, Sally Stenson, Keith Branson, Rose Blitz, Sarah Luke, Bernadette Nazareth, Anne Ben-Smith, Paul E M Fine, Hazel M Dockrell
Affiliations
Clinical Trial

Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: comparison with Glaxo-Evans 1077 BCG vaccine

Patricia Gorak-Stolinska et al. Vaccine. .

Abstract

The immunogenicity and reactogenicity, in British schoolchildren, of the newly introduced Danish-SSI 1331 BCG vaccine was compared with that of the previously used Glaxo-Evans 1077 BCG vaccine. Interferon-gamma (IFN-gamma) response to M. tuberculosis purified protein derivative (M.tb PPD) in a 6-day whole blood assay and delayed type hypersensitivity (DTH) to tuberculin PPD were determined before and 1 year after receiving BCG or no vaccination. Scar size was measured 1 year after vaccination. There was no evidence of a difference in immunogenicity (IFN-gamma and DTH conversion rates) but evidence of lower reactogenicity (scar size) with Danish-SSI 1331 compared to Glaxo-Evans 1077 vaccines.

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