Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 Jun;50(6):2234-6.
doi: 10.1128/AAC.01600-05.

Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

Colin S Osborne  1 , Ingrid Leitner, Bettina Hofbauer, Ceri A Fielding, Bertrand Favre, Neil S Ryder
Affiliations
Comparative Study

Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

Colin S Osborne et al. Antimicrob Agents Chemother. 2006 Jun.

Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Protein sequence alignment (ClustalW) (2) of fungal and mammalian SEs in the region in which several amino acid substitutions (wild-type residues are underlined), affecting the susceptibility of fungi to terbinafine, were found. Key: *, identical between sequences, :, conserved substitution; ·, semiconserved substitution; _, wild type.
See this image and copyright information in PMC

References

    1. Bradley, M. C., S. Leidich, N. Isham, B. E. Elewski, and M. A. Ghannoum. 1999. Antifungal susceptibilities and genetic relatedness of serial Trichophyton rubrum isolates from patients with onychomycosis of the toenail. Mycoses 42:105-110. - PubMed
    1. Chenna, R., H. Sugawara, T. Koike, R. Lopez, T. J. Gibson, D. G. Higgins, and J. D. Thompson. 2003. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31:3497-5300. - PMC - PubMed
    1. da Silva Ferreira, M. E., J. L. Capellaro, E. dos Reis Marques, I. Malavazi, D. Perlin, S. Park, J. B. Anderson, A. L. Colombo, B. A. Arthington-Skaggs, M. H. Goldman, and G. H. Goldman. 2004. In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance. Antimicrob. Agents Chemother. 48:4405-4413. - PMC - PubMed
    1. Favre, B., and N. S. Ryder. 1996. Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob. Agents Chemother. 40:443-447. - PMC - PubMed
    1. Favre, B., and N. S. Ryder. 1997. Differential inhibition of fungal and mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine. Arch. Biochem. Biophys. 340:265-269. - PubMed

Publication types

Associated data

LinkOut - more resources