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. 2006 Jun;50(6):2265-7.
doi: 10.1128/AAC.00190-06.

Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats

Claire Dahyot  1 , Sandrine Marchand, Greisiele Lorena Pessini, Claudine Pariat, Bertrand Debaene, William Couet, Olivier Mimoz
Affiliations

Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats

Claire Dahyot et al. Antimicrob Agents Chemother. 2006 Jun.

Abstract

The aim of this study was to investigate imipenem distribution in muscle and lung interstitial fluids of rats with Acinetobacter baumannii pulmonary infection. By combining microdialysis in blood and tissues, it was possible to demonstrate that free imipenem concentrations were virtually identical in blood, muscle, and lung.

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Figures

FIG. 1.
FIG. 1.
Individual unbound concentrations of IPM in rats with A. baumannii pneumonia treated by a 30-min intravenous infusion of 30 mg · kg−1 of IPM. Solid ovals, blood; open ovals, muscle; solid triangles, lung.
See this image and copyright information in PMC

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