doi: 10.1016/0047-6374(75)90002-0.
Adrenergic beta-receptor activity and cyclic AMP metabolism in vascular smooth muscle; variations with age
- PMID: 167239
- DOI: 10.1016/0047-6374(75)90002-0
Item in Clipboard
Adrenergic beta-receptor activity and cyclic AMP metabolism in vascular smooth muscle; variations with age
Mech Ageing Dev.
1975 Jan-Feb.
Abstract
The relaxing effect of isoproterenol on aortic strips from rats decreases and disappears with increasing age of the animal. In aortas from young rats (1 month) the cAMP level increases after stimulation with isoproterenol (3.6 muM), whereas in old aortas (6 months) the cAMP level was unchanged. Basal and NaF stimulated adenyl cyclase activities are increased in aortas from rats 6 months of age compared with those one month old. The phosphodiesterase activities decrease with increasing age both low (10-7M) and high (10-4M) substrate concentration.
Similar articles
-
Adenyl cyclase-phosphodiesterase system in arterial smooth muscle.Life Sci I. 1972 Sep 1;11(17):817-24. Life Sci I. 1972. PMID: 4347988 No abstract available.
-
Cyclic adenosine monophosphate and hypertension in rats.Science. 1973 Feb 23;179(4075):807-9. doi: 10.1126/science.179.4075.807. Science. 1973. PMID: 4346170
-
Aberrations of cyclic nucleotide metabolism in the hearts and vessels of hypertensive rats.Proc Natl Acad Sci U S A. 1974 Dec;71(12):4930-4. doi: 10.1073/pnas.71.12.4930. Proc Natl Acad Sci U S A. 1974. PMID: 4155074 Free PMC article.
-
Cyclic nucleotides and smooth muscle.Adv Cyclic Nucleotide Res. 1974;4(0):195-237. Adv Cyclic Nucleotide Res. 1974. PMID: 4152823 Review. No abstract available.
-
Cyclic AMP synthesis and hydrolysis in the normal and failing heart.Pflugers Arch. 2014 Jun;466(6):1163-75. doi: 10.1007/s00424-014-1515-1. Epub 2014 Apr 24. Pflugers Arch. 2014. PMID: 24756197 Review.
Cited by
-
Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing.Drugs Aging. 2008;25(5):415-43. doi: 10.2165/00002512-200825050-00005. Drugs Aging. 2008. PMID: 18447405 Review.
-
Density and ultrastructure of mast cells in lung vessels of aging rats exposed to and recovering from chronic hypoxia.Cell Tissue Res. 1983;232(3):601-8. doi: 10.1007/BF00216432. Cell Tissue Res. 1983. PMID: 6883459
-
Age-related changes in vascular smooth muscle and endothelium.Drugs Aging. 1995 Oct;7(4):278-91. doi: 10.2165/00002512-199507040-00003. Drugs Aging. 1995. PMID: 8535055 Review.
-
Thyroxine treatment of aged or young rats demonstrates that vascular responses mediated by beta-adrenoceptor subtypes can be differentially regulated.Br J Pharmacol. 1986 May;88(1):41-9. doi: 10.1111/j.1476-5381.1986.tb09469.x. Br J Pharmacol. 1986. PMID: 2871884 Free PMC article.
-
Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation.Braz J Med Biol Res. 2016 Jul 4;49(7):e5285. doi: 10.1590/1414-431X20165285. Braz J Med Biol Res. 2016. PMID: 27383122 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
