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. 1983 Sep;20(3):363-5.
doi: 10.1016/0093-691x(83)90070-5.

Prevention of the luteolytic action of oxytocin in the goat by inhibition of prostaglandin synthesis

R G Cooke  1 , A M Homeida
Affiliations

Prevention of the luteolytic action of oxytocin in the goat by inhibition of prostaglandin synthesis

R G Cooke et al. Theriogenology. 1983 Sep.

Abstract

Oxytocin-induced luteolysis in goats was associated with significant increases in peripheral plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F2alpha (PGFM). Oral administration of the prostaglandin (PG) synthetase inhibitor meclofenamic acid (l g/day) prevented both the luteolytic action of oxytocin and the increase in PGFM concentrations. These results confirm that the luteolytic effect of oxytocin is mediated via the production and release of PGF2alpha.

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