Review
doi: 10.1016/j.humimm.2006.03.007.
Epub 2006 Apr 3.
Comparative genetics of MHC polymorphisms in different primate species: duplications and deletions
Affiliations
- PMID: 16728259
- DOI: 10.1016/j.humimm.2006.03.007
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Review
Comparative genetics of MHC polymorphisms in different primate species: duplications and deletions
Hum Immunol.
2006 Jun.
Abstract
Gene products of the major histocompatibility complex (MHC) play a crucial role in the activation of adaptive (antigen-dependent) immune responses. In this paper similarities and dissimilarities among the MHCs of different primate species and their functional implications are reviewed. The human HLA system represents the most thoroughly investigated MHC of any contemporary living primate species, and so it will serve as a reference.
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