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. 2006 May 29:3:39.
doi: 10.1186/1743-422X-3-39.

In vitro inhibition of human influenza A virus replication by chloroquine

Eng Eong Ooi  1 , Janet Seok Wei Chew, Jin Phang Loh, Robert C S Chua
Affiliations

In vitro inhibition of human influenza A virus replication by chloroquine

Eng Eong Ooi et al. Virol J. .

Abstract

Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.

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