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. 2006 Jun 29;24(26):5481-90.
doi: 10.1016/j.vaccine.2006.03.089. Epub 2006 Apr 18.

A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure

Adriaan F G Antonis  1 , Christianne J M Bruschke, Paloma Rueda, Luis Maranga, J Ignacio Casal, Carmen Vela, Luuk A Th Hilgers, Peter B G M Belt, Klaas Weerdmeester, Manuel J T Carrondo, Jan P M Langeveld
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A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure

Adriaan F G Antonis et al. Vaccine. .

Abstract

A novel vaccine against porcine parvovirus (PPV), composed of recombinant virus-like particles (PPV-VLPs) produced with the baculovirus expression vector system (BEVS) at industrial scale, was tested for its immunogenicity and protective potency. A formulation of submicrogram amounts of PPV-VLPs in a water-in-mineral oil adjuvant evoked high serum antibody titres in both guinea pigs, used as reference model, and target species, pigs. A single immunisation with 0.7microg of this antigen yielded complete foetal protection against PPV infection after challenge with a virulent strain of this virus. Furthermore, also in the presence of mild adjuvants the protective action of these PPV-VLPs is excellent. This recombinant subunit vaccine overcomes some of the drawbacks of classical PPV vaccines.

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