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Review
. 2006 Apr;17(2):264-73.
doi: 10.1016/j.semcdb.2006.03.009. Epub 2006 Apr 3.

PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals

K Swann  1 , C M Saunders, N T Rogers, F A Lai
Affiliations
Review

PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals

K Swann et al. Semin Cell Dev Biol. 2006 Apr.

Abstract

At fertilization in mammals, the sperm activates development by causing a prolonged series of intracellular Ca(2+) oscillations that are generated by increased production of inositol trisphosphate (InsP(3)). It appears that the sperm initiates InsP(3) generation via the introduction of a sperm factor into the egg after gamete membrane fusion. We recently identified a sperm-specific form of phospholipase C (PLC), referred to as PLCzeta(zeta). We review the evidence that PLCzeta represents the sperm factor that activates development of the egg and discuss the characteristics of PLCzeta that distinguish it from the somatic forms of PLC.

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