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. 2006 Jun;39(6):658-61.
doi: 10.1016/j.clinbiochem.2006.03.017. Epub 2006 Apr 21.

Cystatin C reference values and aging

Agostino Ognibene  1 , Edoardo Mannucci, Anna Caldini, Alessandro Terreni, Marco Brogi, Gianluca Bardini, Iolanda Sposato, Valentina Mosconi, Benedetta Salvadori, Carlo Maria Rotella, Gianni Messeri
Affiliations

Cystatin C reference values and aging

Agostino Ognibene et al. Clin Biochem. 2006 Jun.

Abstract

Objectives: The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging.

Design and methods: The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected.

Results: CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L).

Conclusions: The use of CysC reference values adjusted for age should be carefully taken into consideration.

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