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. 2006 Aug 1;16(15):3960-5.
doi: 10.1016/j.bmcl.2006.05.022. Epub 2006 May 30.

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease

Ashok Arasappan  1 , F George Njoroge, Kevin X Chen, Srikanth Venkatraman, Tejal N Parekh, Haining Gu, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Vincent Madison, Viyyoor Girijavallabhan
Affiliations

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease

Ashok Arasappan et al. Bioorg Med Chem Lett. .

Abstract

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.

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