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Comparative Study
. 1991 Apr 18;350(6319):585-9.
doi: 10.1038/350585a0.

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

J C Izpisúa-Belmonte  1 , C Tickle, P Dollé, L Wolpert, D Duboule
Affiliations
Comparative Study

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

J C Izpisúa-Belmonte et al. Nature. .

Abstract

The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.

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