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Clinical Trial
. 1991 May 4;337(8749):1062-3.
doi: 10.1016/0140-6736(91)91709-4.

Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist

K P Hui  1 , N C Barnes
Affiliations
Clinical Trial

Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist

K P Hui et al. Lancet. .

Abstract

In a double-blind study ten asthmatic patients with impaired lung function received the cysteinyl-leukotriene receptor antagonist ICI 204,219 (40 mg by mouth) and placebo in random order on 2 days at least 1 week apart. The increase in forced expiratory volume in 1 s (FEV1) above baseline was significantly greater after ICI 204,219 than after placebo. This effect persisted after nebulised salbutamol. These findings suggest that cysteinyl-leukotrienes are one of the causes of persistent bronchoconstriction in chronic asthma.

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