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. 2006:2:2006.0002.
doi: 10.1038/msb4100044. Epub 2006 Jan 17.

Circuit diagrams for biological networks

Kurt W Kohn, Mirit I Aladjem

Circuit diagrams for biological networks

Kurt W Kohn et al. Mol Syst Biol. 2006.
No abstract available

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Figures

Figure 1
Figure 1
An SBGN process diagram (A) and a molecular interaction map (B) of a signaling pathway triggered by ligand binding to EGFR molecules. Both diagrams depict ligand-activated phosphorylation and dimerization of EGFR, followed by a phosphorylation cascade involving membrane-bound and cytoplasmic kinases. Phosphorylated kinases (ERK, Rsk2) can transport to the nucleus, where they may activate transcription via the phosphorylation of nuclear transcription factors (myc and CREB). Panel A depicts this pathway as a process diagram (for symbols, see Kitano et al, 2005; Oda et al, 2005); panel B depicts the same pathway as a molecular interaction map (for symbols, see Kohn, 1999, 2001; Kohn et al, 2005).
See this image and copyright information in PMC

References

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    1. Kohn KW (1999) Molecular interaction map of the mammalian cell cycle control and DNA repair systems. Mol Biol Cell 10: 2703–2734 - PMC - PubMed

Publication types