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. 2006 Jun;8(6):640-2.
doi: 10.1038/ncb1417.

The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair

Tomoo Ogi  1 , Alan R Lehmann
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The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair

Tomoo Ogi et al. Nat Cell Biol. 2006 Jun.

Abstract

DNA polymerase kappa (pol kappa) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol kappa-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol kappa in mammalian NER.

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  • Survival choices.
    Kunkel TA, Van Houten B. Kunkel TA, et al. Nat Cell Biol. 2006 Jun;8(6):547-9. doi: 10.1038/ncb0606-547. Nat Cell Biol. 2006. PMID: 16738701 No abstract available.

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