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Comment
. 2006 Jun;188(12):4165-8.
doi: 10.1128/JB.00311-06.

Census of prokaryotic senses

Robert B Bourret  1
Affiliations
Comment

Census of prokaryotic senses

Robert B Bourret. J Bacteriol. 2006 Jun.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Domain architecture of signaling proteins. (A) Prototypical example of a two-component regulatory system. Stimulus detection by the input domain regulates autophosphorylation of the transmitter domain. Phosphotransfer to the receiver domain regulates activity of the output domain, which implements the adaptive response. (B) Response regulators that appear to have histidine kinase enzymatic output domains. In addition to the receiver-transmitter architecture depicted, examples of receiver-transmitter-receiver and receiver-receiver-transmitter were also observed (6). (C) A common permutation of two-component regulatory systems is a four-step phosphorelay, which is often initiated by a hybrid kinase, in which a receiver domain is fused to a sensor kinase. Transmitter autophosphorylation and phosphotransfer to the receiver occur within the hybrid kinase. The phosphoryl group is subsequently transferred to a histidine phosphotransferase domain and, finally, to the receiver domain of a standard response regulator (not shown). (D) One-component systems contain direct fusions of input and output domains (21).
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References

    1. Amann, R. L., W. Ludwig, and K.-H. Schleifer. 1995. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol. Rev. 59:143-169. - PMC - PubMed
    1. Ashby, M. K. 2004. Survey of the number of two-component response regulator genes in the complete and annotated genome sequences of prokaryotes. FEMS Microbiol. Lett. 231:277-281. - PubMed
    1. Catlett, N. L., O. C. Yoder, and B. G. Turgeon. 2003. Whole-genome analysis of two-component signal transduction genes in fungal pathogens. Eukaryot. Cell 2:1151-1161. - PMC - PubMed
    1. Fraser-Liggett, C. M. 2005. Insights on biology and evolution from microbial genome sequencing. Genome Res. 15:1603-1610. - PubMed
    1. Galperin, M. Y. February 2006, posting date. Response regulators encoded in bacterial and archaeal genomes. [Online.] http://www.ncbi.nlm.nih.gov/Complete_Genomes/RRcensus.html.

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