Comment
. 2006 Jun 2;312(5778):1312; author reply 1312.
doi: 10.1126/science.1124608.
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"
Affiliations
- PMID: 16741098
- DOI: 10.1126/science.1124608
Item in Clipboard
Comment
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"
Science.
.
Abstract
Calorie restriction (CR) increases life span in yeast independently of Sir2. Lamming et al. (Reports, 16 September 2005, p. 1861) recently proposed that Sir2-independent life-span extension by CR is mediated by the Sir2 paralogs Hst1 and Hst2. Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1.
Comment on
-
HST2 mediates SIR2-independent life-span extension by calorie restriction.Science. 2005 Sep 16;309(5742):1861-4. doi: 10.1126/science.1113611. Epub 2005 Jul 28. Science. 2005. PMID: 16051752
Similar articles
-
Sir2 and calorie restriction in yeast: a skeptical perspective.Ageing Res Rev. 2007 Aug;6(2):128-40. doi: 10.1016/j.arr.2007.04.001. Epub 2007 Apr 19. Ageing Res Rev. 2007. PMID: 17512264 Review.
-
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.Aging Cell. 2006 Dec;5(6):505-14. doi: 10.1111/j.1474-9726.2006.00240.x. Aging Cell. 2006. PMID: 17129213
-
HST2 mediates SIR2-independent life-span extension by calorie restriction.Science. 2005 Sep 16;309(5742):1861-4. doi: 10.1126/science.1113611. Epub 2005 Jul 28. Science. 2005. PMID: 16051752
-
Sir2 blocks extreme life-span extension.Cell. 2005 Nov 18;123(4):655-67. doi: 10.1016/j.cell.2005.08.042. Cell. 2005. PMID: 16286010
-
Sound silencing: the Sir2 protein and cellular senescence.Bioessays. 2001 Apr;23(4):327-32. doi: 10.1002/bies.1047. Bioessays. 2001. PMID: 11268038 Review.
Cited by
-
Global heterochromatin loss: a unifying theory of aging?Epigenetics. 2012 Jul;7(7):680-8. doi: 10.4161/epi.20540. Epub 2012 Jul 1. Epigenetics. 2012. PMID: 22647267 Free PMC article.
-
Recent developments in yeast aging.PLoS Genet. 2007 May 25;3(5):e84. doi: 10.1371/journal.pgen.0030084. PLoS Genet. 2007. PMID: 17530929 Free PMC article. Review.
-
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.Cell. 2008 Apr 18;133(2):292-302. doi: 10.1016/j.cell.2008.02.037. Cell. 2008. PMID: 18423200 Free PMC article.
-
Yeast as a model to understand the interaction between genotype and the response to calorie restriction.FEBS Lett. 2012 Aug 31;586(18):2868-73. doi: 10.1016/j.febslet.2012.07.038. Epub 2012 Jul 22. FEBS Lett. 2012. PMID: 22828279 Free PMC article. Review.
-
Nutritional Control of Chronological Aging and Heterochromatin in Saccharomyces cerevisiae.Genetics. 2017 Mar;205(3):1179-1193. doi: 10.1534/genetics.116.196485. Epub 2017 Jan 6. Genetics. 2017. PMID: 28064165 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
