[Genetics and schizophrenia]

Abstract

Studies of twins, adoption and familial incidence have demonstrated that heredity plays a role in the genesis of schizophrenia. Owing to recent advances in molecular biology and computerized statistical models, analyses of pedigrees and genetic linkage have made it possible to progress in the identification and mode of transmission of genetic factors in schizophrenia. The methodology and conflicting results of these studies are reviewed, together with modern hypotheses on the mode of transmission of schizophrenia. The contribution of genetic studies to the concept of schizophrenia clinical spectrum and the new strategies of research in genetics are presented.