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. 1991 Apr;44(4):343.
doi: 10.1136/jcp.44.4.343.

Lack of C-erbB-2 protein expression in pulmonary carcinoid tumours

N Wilkinson  1 , P S Hasleton, S Wilkes, A Quigley
Affiliations

Lack of C-erbB-2 protein expression in pulmonary carcinoid tumours

N Wilkinson et al. J Clin Pathol. 1991 Apr.

Abstract

To determine if amplification of the C-erb-B2 proto-oncogene could be correlated with prognosis in carcinoid tumours, 49 pulmonary carcinoid tumours (26 typical, 23 atypical) were examined using a polyclonal antibody to the C-terminal peptide of the C-erb-B2 protein sequence. No C-erb-B2 gene product could be shown: the demonstration of C-erb-B2 does not seem to help, therefore, in determining diagnosis or prognosis in pulmonary carcinoid tumours.

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