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. 1967 Dec;105(3):921-6.
doi: 10.1042/bj1050921.

The composition of crystalline complexes of neurophysin-M with [8-arginine]-vasopressin and oxytocin

M D Hollenberg  1 , D B Hope
Affiliations

The composition of crystalline complexes of neurophysin-M with [8-arginine]-vasopressin and oxytocin

M D Hollenberg et al. Biochem J. 1967 Dec.

Abstract

Neurophysin-M, a methionine-containing protein that is the major constituent of neurophysin, has been crystallized as complexes with [8-arginine]-vasopressin. Three moles of vasopressin alone or 2 moles of vasopressin together with 1 mole of oxytocin are bound/mole of protein. An amorphous complex of the protein with oxytocin alone contains 2 moles of the hormone/mole of protein. Deamino-[8-arginine]-vasopressin, a highly active basic analogue of vasopressin, is not bound by neurophysin. The primary amino group of both vasopressin and oxytocin is necessary for binding with neurophysin.

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References

    1. Proc Natl Acad Sci U S A. 1966 Aug;56(2):640-6 - PubMed
    1. Br J Pharmacol Chemother. 1966 Feb;26(2):502-10 - PubMed
    1. Biochem J. 1967 Jul;104(1):122-7 - PubMed
    1. Br J Pharmacol Chemother. 1952 Dec;7(4):567-72 - PubMed
    1. J Lab Clin Med. 1956 Aug;48(2):311-4 - PubMed