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. 1973 Jun;134(2):651-3.
doi: 10.1042/bj1340651.

Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication)

S Whitehouse  1 , P J Randle
Affiliations

Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication)

S Whitehouse et al. Biochem J. 1973 Jun.

Abstract

The activity of pyruvate dehydrogenase was assayed in extracts of rat hearts perfused in vitro with media containing glucose and insulin+/-acetate+/-dichloroacetate. Dichloroacetate (100mum, 1mm or 10mm) increased the activity of pyruvate dehydrogenase in perfusions with glucose or glucose+acetate. Evidence is given that dichloroacetate may facilitate the conversion of pyruvate dehydrogenase from an inactive (phosphorylated) form into an active (dephosphorylated) form.

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