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Case Reports
. 1991 Jun 8;337(8754):1373-4.
doi: 10.1016/0140-6736(91)93059-i.

Is adult-onset coeliac disease due to a low-grade lymphoma of intraepithelial T lymphocytes?

D H Wright  1 , D B Jones, H Clark, G M Mead, E Hodges, W M Howell
Affiliations
Case Reports

Is adult-onset coeliac disease due to a low-grade lymphoma of intraepithelial T lymphocytes?

D H Wright et al. Lancet. .

Abstract

Enteropathy-associated T-cell lymphoma commonly presents with malabsorption, and debate continues as to whether adult-onset coeliac disease (CD) is itself a form of low-grade lymphoma. A 59-year-old man with adult-onset CD required resection of a segment of oedematous jejunum. Histological examination of this tissue revealed an intense intraepithelial lymphocytosis. Immunophenotypic (CD3-, CD4-, CD8-, CD34-, and CD45 RO-) and cytogenetic (deletion of the Y chromosome and chromosome 9) abnormalities were found, together with monoclonal T-cell-receptor gene rearrangements. Some patients with adult-onset CD may have low-grade lymphoma from the outset of their illness.

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  • Coeliac disease and lymphoma.
    [No authors listed] [No authors listed] Lancet. 1991 Aug 3;338(8762):318-9. Lancet. 1991. PMID: 1677139 No abstract available.

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