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Comparative Study
. 1991 May 15;176(3):1610-6.
doi: 10.1016/0006-291x(91)90472-j.

Primary structure of mouse tyrosine hydroxylase deduced from its cDNA

S Ichikawa  1 , T Sasaoka, T Nagatsu
Affiliations
Comparative Study

Primary structure of mouse tyrosine hydroxylase deduced from its cDNA

S Ichikawa et al. Biochem Biophys Res Commun. .

Abstract

The cDNAs for tyrosine hydroxylase were cloned from a mouse brain cDNA library by plaque hybridization. Since the longest cDNA clone lacked approximately 150 bp sequence of its N-terminal region, additional 5' region was obtained using polymerase chain reaction. Nucleotide sequence determination of cDNAs revealed that mouse tyrosine hydroxylase m-RNA encodes 498 amino acids with a calculated molecular mass of 55,990. The amino acid sequence of mouse tyrosine hydroxylase is highly homologous to rat (97%) and human (92%) enzymes.

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