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Review
. 2006 Dec:100 Suppl 1:S41-4.
doi: 10.1016/j.trstmh.2006.02.009. Epub 2006 Jun 5.

Miltefosine: issues to be addressed in the future

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Review

Miltefosine: issues to be addressed in the future

J Berman et al. Trans R Soc Trop Med Hyg. 2006 Dec.

Abstract

Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice conditions, generation of drug resistance and the need to provide a second antileishmanial agent to protect against this disastrous event, and the ability to maintain reproductive contraceptive practices under routine clinical conditions.

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