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Review
. 2006 Jun 2;125(5):834-6.
doi: 10.1016/j.cell.2006.05.014.

Sorting out Toll signals

Katherine A Fitzgerald  1 , Zhijian J Chen
Affiliations
Free article
Review

Sorting out Toll signals

Katherine A Fitzgerald et al. Cell. .
Free article

Abstract

Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

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