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. 2007 Mar;60(3):311-4.
doi: 10.1136/jcp.2006.037820. Epub 2006 Jun 2.

Accuracy and clinical utility of the CoaguChek XS portable international normalised ratio monitor in a pilot study of warfarin home-monitoring

Luke R Bereznicki  1 , Shane L Jackson, Gregory M Peterson, Ella C Jeffrey, Katherine A Marsden, David M Jupe
Affiliations

Accuracy and clinical utility of the CoaguChek XS portable international normalised ratio monitor in a pilot study of warfarin home-monitoring

Luke R Bereznicki et al. J Clin Pathol. 2007 Mar.

Abstract

Aim: To evaluate the accuracy of the CoaguChek XS international normalised ratio (INR) monitor compared with the laboratory method.

Methods: The accuracy and ease of use of the recently marketed CoaguChek XS portable INR monitor was evaluated in 17 patients involved in a trial of warfarin home monitoring. INR results from the monitor were compared with those from the laboratory method. Clinical applicability was measured by discrepant INR values, defined in the literature by expanded and narrow agreement criteria, and by the proportion of INR values differing by >15% and by >20% from those derived by the laboratory method.

Results: Participants provided 59 comparison INR measurements for analysis. The paired results were highly correlated (r = 0.91). Expanded and narrow agreement between paired INR values occurred 100% of the time. Only three CoaguChek XS (5.1%) results differed by >15% compared with the laboratory method; no results differed by >20% or were discrepant by >0.5 INR units.

Conclusions: In the hands of patients the CoaguChek XS showed good correlation with laboratory determination of INR and compared well with expanded and narrow clinical agreement criteria. Both patients and doctors were highly satisfied with the accuracy and ease of use of the CoaguChek XS.

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Conflict of interest statement

Competing interests: None.

References

    1. Gallus A. Towards the safer use of warfarin I: an overview. J Qual Clin Pract 19991955–59. - PubMed
    1. Price C P. Point of care testing. BMJ 20013221285–1288. - PMC - PubMed
    1. Peterson G M, Boom K, Jackson S L.et al Doctors' beliefs on the use of antithrombotic therapy in atrial fibrillation: identifying barriers to stroke prevention. Int Med J 20023215–23. - PubMed
    1. Leichsenring I, Plesch W, Unkrig V.et alResults of the master lot calibration of a new coagulation monitoring system for patient self‐testing [poster]. Sydney, Australia: XXth ISTH Congress, 2005
    1. Douketis J D, Lane A, Milne J.et al Accuracy of a portable international normalization ratio monitor in outpatients receiving long‐term oral anticoagulant therapy: comparison with a laboratory reference standard using clinically relevant criteria for agreement. Thromb Res 19989211–17. - PubMed

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